The Gaudet Lab

PUBLICATIONS   

Lee SE, Park S-H, Aldrich JC, Fonken LK, Gaudet AD. Anxiety-like behaviors in mice unmasked: revealing sex differences in anxiety using a novel light-heat conflict test. Journal of Neuroscience Research. 2024. 102: e70002. doi: https://doi.org/10.1002/jnr.70002 // .pdf

Aldrich JC, Scheinfeld AR, Lee SE, Dusenbery KJ, Mahach KM, Van de Veire BC, Fonken LK, Gaudet AD. Effects of dim light at night in C57BL6/J mice on recovery after spinal cord injury. Experimental Neurology. 2024. 375: 114725. doi: https://doi.org/10.1016/j.expneurol.2024.114725
Available on BioRxiv: https://doi.org/10.1101/2023.09.15.557980
Dataset: Open Data Commons for Spinal Cord Injury. ODC-SCI:956 http://dx.doi.org/10.34945/F5N30H

Lee SE, Park S-H, Aldrich JC, Fonken LK, Gaudet AD. Anxiety-like behaviors in mice unmasked: Revealing sex differences in anxiety using a novel light-heat conflict test. bioRxiv. 2022.09.02.506410; doi: https://doi.org/10.1101/2022.09.02.506410

Gaudet AD, Greenough EK. “Circadian Rhythms Regulate Neuroinflammation after Traumatic Brain Injury and Spinal Cord Injury,” in Biological Implications of Circadian Disruption. Cambridge University Press, 2023. Eds: Fonken LK, Nelson RJ. doi: https://doi.org/10.1017/9781009057646

Chen R, Routh BN, Straetker JE, Gibson CR, Weitzner AS, Bell KS, Gaudet AD, Fonken LK. Microglia depletion ameliorates neuroinflammation, anxiety-like behavior, and cognitive deficits in a sex-specific manner in Rev-erbα knockout mice. Brain, Behavior, and Immunity. 2023; 114:287-298. DOI: https://doi.org/10.1016/j.bbi.2023.08.029

Ince LM, Darling JS, Sanchez K, Bell KS, Melbourne JK, Davis LK, Nixon K, Gaudet AD, Fonken LK. Sex differences in microglia function in aged rats underlie vulnerability to cognitive decline. Brain, Behavior, and Immunity. 2023. 114:438-452. DOI: 10.1016/j.bbi.2023.09.009

Chen R, Routh BN, Gaudet AD, Fonken LK. Circadian regulation of the neuroimmune environment across the lifespan: From brain development to aging. Journal of Biological Rhythms. 2023:7487304231178950.

Lee SE, Greenough EK, Fonken LK, Gaudet AD. Spinal cord injury in mice amplifies anxiety: a novel light-heat conflict test exposes increased salience of anxiety over heat. Experimental Neurology. 2023.114382. doi: 10.1016/j.expneurol.2023.114382. .pdf here
Available on BioRxiv: https://doi.org/10.1101/2023.01.13.523970

Lee SE, Greenough EK, Oancea P, Scheinfeld AR, Douglas AM, Gaudet AD. Sex differences in pain: Spinal cord injury in female and male mice elicits behaviors related to neuropathic pain. Journal of Neurotrauma. 2023. doi: https://doi.org/10.1089/neu.2022.0482
Also on BioRxiv: https://doi.org/10.1101/2022.10.18.512805
Dataset: Open Data Commons for Spinal Cord Injury. ODC-SCI:893 http://dx.doi.org/10.34945/F5SW2F

Fonken LK, Gaudet AD. Neuroimmunology of healthy brain aging. Current Opinion in Neurobiology. 2022. 77:102649. https://doi.org/10.1016/j.conb.2022.102649

Lee W, Milewski TM, Dwortz MF, Young RL, Gaudet AD, Fonken LK, Champagne FA, Curley JP. Distinct inflammatory and transcriptomic profiles in dominant versus subordinate males in mouse social hierarchies. Brain, Behavior, and Immunity. 2022. 103:130-144.

Gaudet AD, Fonken LK, Ayala MT, Maier SF, Watkins LR. Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury. Brain, Behavior, and Immunity. 2021; 97: 365-70.

Darling JS, Sanchez K, Gaudet AD, Fonken LK. “The Role of Microglia in the Aging Brain: A Focus on Sex Differences,” in Oxford Research Encyclopedia of Neuroscience. Oxford, U.K.: Oxford University Press, 2020.

Gaudet AD, Fonken LK, Ayala MT, D’Angelo HM, Smith EJ, Bateman EM, Schleicher WE, Maier SF, Watkins LR. Spinal cord injury in rats dysregulates diurnal rhythms of fecal output and liver metabolic indicators. Journal of Neurotrauma. 2019; 36 (12): 1923-34. .pdf

Gaudet AD, Fonken LK, Ayala MT, Bateman EM, Schleicher WE, Smith EJ, D’Angelo HM, Maier SF, Watkins LR. Spinal cord injury in rats disrupts diurnal rhythms. eNeuro. 2018; 5(6): e0328-18.2018.
** Covered in press: UT press release; Science Daily; Sleep Review; The Spin magazine

Fonken LK, Frank MG, Gaudet AD, Maier SF. Stress and aging act through common mechanisms to elicit neuroinflammatory priming. Brain, Behavior, and Immunity. 2018; pii:S0889-1591(18)30334-9.

Gaudet AD, Fonken LK. Glial cells shape pathology and repair after spinal cord injury. Neurotherapeutics. 2018; 15 (3): 554-577

Fonken LK, Frank MG, Gaudet AD, D’Angelo HM, Daut RA, Hampson EC, Ayala MT, Watkins LR, Maier SF. Neuroinflammatory priming to stress is differentially regulated in male and female rats. Brain, Behavior, and Immunity. 2018; pii:S0889-1591(18)30049-7. 

>> We have also published opinion articles in Science and Naturejobs discussing strategies for trainee productivity (here and here), for creating engaging presentations, and for finding an effective mentor. Please see “Other Publications” below for details. <<

Bateman EM, Schleicher WE, Smith EJ, Sweet DR, Gaudet AD. Journal Club: MRI reveals acute inflammation in cortical lesions during early MS. Neurology. 2018; 90:e724-726. 

Gaudet AD, Fonken LK, Watkins LR, Nelson RJ, Popovich PG. microRNAs: Roles in regulating neuroinflammation. Neuroscientist. 2017; 1073858417721150. 

Gaudet AD, Ayala MT, Schleicher WE, Smith EJ, Bateman EM, Maier SF, Watkins LR. Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury. Experimental Neurology. 2017; 295:46-54.

Grace PM, Gaudet AD, Staikopoulos V, Maier SF, Hutchinson MR, Salvemini D, Watkins LR. Nitroxidative signaling mechanisms in pathological pain. Trends in Neuroscience. 2016; 39(12):862-879.

Fonken LK, Kitt MM, Gaudet AD, Barrientos RM, Watkins LR, Maier SF. Diminished circadian rhythms in microglia may contribute to age-related neuroinflammatory sensitization. Neurobiology of Aging. 2016; 47:102-112.

Gaudet AD, Mandrekar-Colucci S, Hall JCE, Sweet DR, Schmitt PJ, Xu X, Guan Z, Mo X, Guerau-de-Arellano M, Popovich PG. miR-155 deletion in mice overcomes neuron-intrinsic and neuron-extrinsic barriers to spinal cord repair. Journal of Neuroscience. 2016; 36(32):8516-8532. 

 Jablonski K, Gaudet AD, Amici S, Popovich PG, Guerau-de-Arellano M. Control of the inflammatory macrophage transcriptional signature by miR-155. PLoS ONE. 2016; 11(7):e0159724. 

Gaudet AD*, Fonken LK*, Gushchina LV, Aubrecht TG, Maurya SK, Periasamy M, Nelson RJ, Popovich PG. miR-155 deletion in female mice prevents diet-induced obesity. Scientific Reports. 2016; 6:22862. 
* Contributed equally. 
** Covered in press: Ohio State press release; Food Navigator

Fonken LK*, Gaudet AD*, Gaier KR, Nelson RJ, Popovich PG. microRNA-155 deletion reduces anxiety- and depressive-like behaviors in mice. Psychoneuroendocrinology. 2015; 63:362-369.
* Contributed equally.

Carpenter RS, Kigerl KA, Marbourg JM, Gaudet AD, Huey D, Niewiesk S, Popovich PG. Traumatic spinal cord injury in mice with human immune systems. Experimental Neurology. 2015; 271:432-444. 

Gaudet AD, Sweet DR, Polinski NK, Guan Z, Popovich PG. Galectin-1 in injured rat spinal cord: Implications for macrophage phagocytosis and neural repair. Molecular and Cellular Neuroscience. 2015; 64:84-94.

Gaudet AD, Popovich PG. Extracellular matrix regulation of inflammation in the healthy and injured spinal cord. Experimental Neurology. 2014; 258C:24-34. 

Gensel JC, Kigerl KA, Mandrekar-Colucci SS, Gaudet AD, Popovich PG. Achieving CNS axon regeneration by manipulating convergent neuro-immune signaling. Cell and Tissue Research. 2012; 349(1):201-13.

Gaudet AD, Popovich PG, Ramer MS. Wallerian degeneration: Gaining perspective on inflammatory events after peripheral nerve injury. J Neuroinflammation.2011; 8(1):110. 

Gaudet AD, Ramer LM, Nakonechny J, Cragg JJ, Ramer MS. Small-group learning in an upper-level university biology class enhances academic performance and student attitudes toward group work. PLoS ONE. 2010; 5(12):e15821. 

Gaudet AD, Leung M, Poirier F, Kadoya T, Horie H, Ramer MS. A role for galectin-1 in the immune response to peripheral nerve injury. Experimental Neurology.  2009; 220(2): 320-7. 

Gaudet AD, Ramer LM. Mind the GAP: a role for neurofibromin in restricting axonal plasticity. J Neurosci. 2007; 27(21):5533-4. 

McGraw J, Gaudet AD, Oschipok LW, Kadoya T, Horie H, Steeves JD, Tetzlaff W, Ramer MS. Regulation of neuronal and glial galectin-1 expression by peripheral and central axotomy of rat primary afferent neurons.  Experimental Neurology. 2005; 195(1):103-14. 

McGraw J*, Gaudet AD*, Oschipok LW, Steeves JD, Poirier F, Tetzlaff W, Ramer MS. Altered primary afferent anatomy and reduced thermal sensitivity in mice lacking galectin-1.  Pain. 2005; 114(1-2):7-18. 
* Contributed equally.

Gaudet AD, Steeves JD, Tetzlaff W, Ramer MS. Expression and functions of galectin-1 in sensory and motoneurons. Current Drug Targets. 2005; 6(4):419-25.

Gaudet AD, Williams SJ, Hwi LP, Ramer MS. Regulation of TRPV2 by axotomy in sympathetic, but not sensory neurons.  Brain Research. 2004; 1017(1-2):155-62.

OTHER PUBLICATIONS

Gaudet AD, Fonken LK. “Ten tips for finding an effective mentor.” Naturejobs. Web. 25 January 2017.

Gaudet AD, Fonken LK. “Scientific presentations: A cheat sheet.” Naturejobs. Web. 11 January 2017.

Gaudet A. “A grad school survival guide.” Science. 2015;347(6228):1386. 

Gaudet AD. “Secrets to thriving in graduate school.” Science Careers. Science Magazine. Web. 21 January 2015.